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AICAR is a natural metabolic intermediate of the purine biosynthetic pathway. In its monophosphate form, AICAR is a potent AMPK agonist, which at low concentrations, does not affect AMP, ADP, or ATP levels.  AICAR’s interacts directly with AMPK, inducing a conformational change that favors phosphorylation of the catalytic alpha subunit.
1.It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production.It has a molecular mass of 338.211,and it has a molecular formula of C9H15N4O8P.
2.AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain cellular energy homeostasis (Hardie and Carling).
3.AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine.
4.AICAR can play a important role in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide’s presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.
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